Study of Bioengineered Zebra Fish Olfactory Receptor 131-2: Receptor Purification and Secondary Structure Analysis

Study of Bioengineered Zebra Fish Olfactory Receptor 131-2: Receptor Purification and Secondary Structure Analysis

How fishes are able to detect trace molecules in large bodies of water is not understood. It is plausible that they use olfactory receptors to detect water-soluble compounds. How the zebra fish Danio Rerio, an organism with only 98 functional olfactory receptors, is able to selectively detect and recognize numerous compounds in water remains a puzzling phenomenon. We are interested in studying ...

Olfactory Receptor Neurons in Fish : Structural , Molecular and Functional Correlates

In rodents, the olfactory system is segregated into the main olfactory epithelium (OE) and into the vomeronasal organ (VNO), the former populated by ciliated olfactory receptor neurons (ORNs) expressing the G-protein subunit Gαolf and OR-type odorant receptor molecules, the latter housing microvillous receptor neurons (VRNs) expressing Gαo and Gαi and V1R, V2R and V3R receptor molecules. Projec...

Olfactory receptor neurons in fish: structural, molecular and functional correlates.

A novel olfactory receptor gene family in teleost fish.

While for two of three mammalian olfactory receptor families (OR and V2R) ortholog teleost families have been identified, the third family (V1R) has been thought to be represented by a single, closely linked gene pair. We identified four further V1R-like genes in every teleost species analyzed (Danio rerio, Gasterosteus aculeatus, Oryzias latipes, Tetraodon nigroviridis, Takifugu rubripes). In ...

A Pilot Study of Polymorphism of Adrenergic Beta-2 Receptor and Mild Asthma: A Clinical and Pharmacogenetic Study

Glycine allele at codon 16 has previously been associated with the increase in asthma severity, bronchial hyperresponsiveness and also the increase in inhaled corticosteroid dependence. This study was designed to evaluate the genetic alleles in mild asthma.Thirty-four patients with diagnosis of mild asthma (FEV1 ≥ 80%, positive methacholine test) and body mass index (BMI ≤ 30 Kg/m2) were includ...